Causes, Smoking: "Smoking gun"
This section reviews K-ras and p53, two genes most frequently mutated in smoking-related lung cancers, one tar component, benzo[a]pyrene, is specifically linked to known mutations in these genes.
Educational standards - statements
- Gene mutation in a cell can result in uncontrolled division called cancer. Exposure of cells to certain chemicals and radiation increases mutations and thus the chance of cancer.| AAAS#5C/H6
- Toxic substances, some dietary habits, and some personal behavior may be bad for one's health. Some effects show up right away, others years later. Avoiding toxic substances, such as tobacco, and changing dietary habits increase the chance of living longer.| AAAS#6E/M2
- Many diseases can be prevented, controlled, or cured. Some diseases, such as cancer, result from specific body dysfunctions and cannot be transmitted.| NSES#F 1.2