Stability genes - Revision history

Nash at 14:45, 14 April 2008

Nash — Mon, 14 Apr 2008 14:45:19 GMT

←Older revision		Revision as of 14:45, 14 April 2008
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-	'''== Describe the activity. =='''	+	'''Describe the activity.'''

	Student partners will select (or be assigned) a stability gene and will utilize web-based resources, including www.insidecancer.org, to explore molecular mechanisms by which tumors progress through stages and alter their phenotypes.		Student partners will select (or be assigned) a stability gene and will utilize web-based resources, including www.insidecancer.org, to explore molecular mechanisms by which tumors progress through stages and alter their phenotypes.


-	'''== Time required =='''	+	'''Time required'''

	2-3 class periods, the last of which will include an informal presentation to the rest of the class.		2-3 class periods, the last of which will include an informal presentation to the rest of the class.

Nash at 14:44, 14 April 2008

Nash — Mon, 14 Apr 2008 14:44:53 GMT

←Older revision		Revision as of 14:44, 14 April 2008
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	''' Stability Genes & Their Roles in Carcinogenesis '''		''' Stability Genes & Their Roles in Carcinogenesis '''
-

	----		----
-	'''Lesson Overview'''	+	'''Lesson Overview'''
		+
	Students read an overview of the types of gene mutations can contribute to carcinogenesis. They learn about stability genes and how defects in these genes promote cancer development in the "Promoting Mutations" subsection of the "Hallmarks of Cancer" section of the InsideCancer.org site. Each student pair will select a specific stability gene linked to cancer and will compare its wild type function in normal cells with its transformed function in tumor cells.		Students read an overview of the types of gene mutations can contribute to carcinogenesis. They learn about stability genes and how defects in these genes promote cancer development in the "Promoting Mutations" subsection of the "Hallmarks of Cancer" section of the InsideCancer.org site. Each student pair will select a specific stability gene linked to cancer and will compare its wild type function in normal cells with its transformed function in tumor cells.

Nash at 14:44, 14 April 2008

Nash — Mon, 14 Apr 2008 14:44:28 GMT

←Older revision		Revision as of 14:44, 14 April 2008
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	Students will:		Students will:
		+
	1. Explain what a stability gene is and the role that they play in cancer development and promotion.		1. Explain what a stability gene is and the role that they play in cancer development and promotion.
		+
	2. Choose a specific hallmark gene and describe its role in certain cancers		2. Choose a specific hallmark gene and describe its role in certain cancers

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	'''The Lesson'''		'''The Lesson'''

-	'''Preparation Before class:'''	+	'''Preparation Before class:'''
		+
	A concise document, based on the article "The Hallmarks of Cancer" will be provided to give background about the mechanisms of carcinogenesis.		A concise document, based on the article "The Hallmarks of Cancer" will be provided to give background about the mechanisms of carcinogenesis.

Nash at 14:44, 14 April 2008

Nash — Mon, 14 Apr 2008 14:44:04 GMT

←Older revision		Revision as of 14:44, 14 April 2008
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-	'''== Stability Genes & Their Roles in Carcinogenesis =='''	+	''' Stability Genes & Their Roles in Carcinogenesis '''


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-	'''== Goals and Objectives =='''	+	''' Goals and Objectives '''

	Students will:		Students will:
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	2. Choose a specific hallmark gene and describe its role in certain cancers		2. Choose a specific hallmark gene and describe its role in certain cancers

-	'''==	+	''' Common Misconceptions'''
-	Common Misconceptions =='''	+

	Students are frequently taught that two types of genes mutate during carcinogenesis: those that promote progression through the cell cycle, and those that inhibit such progression. While this generalization is accurate, it is not complete. For example, it leaves out stability gene mutations, which result in an overall net increase in new mutations, thus enhancing the likelihood that tumor cells will develop new phenotypes.		Students are frequently taught that two types of genes mutate during carcinogenesis: those that promote progression through the cell cycle, and those that inhibit such progression. While this generalization is accurate, it is not complete. For example, it leaves out stability gene mutations, which result in an overall net increase in new mutations, thus enhancing the likelihood that tumor cells will develop new phenotypes.
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-	'''== The Lesson =='''	+	'''The Lesson'''
-		+
-		+

-	'''== Preparation Before class: =='''	+	'''Preparation Before class:'''
	A concise document, based on the article "The Hallmarks of Cancer" will be provided to give background about the mechanisms of carcinogenesis.		A concise document, based on the article "The Hallmarks of Cancer" will be provided to give background about the mechanisms of carcinogenesis.

-	'''== During class =='''	+	'''During class'''

-	Initiate discussion with the following question: "If specific cancers arise as a result of, typically, 5-7 mutations in key genes, how does one explain the progression of tumors from being localized in the tissue of origin to being metastatic such that they can invade distant sites in the body?"	+	Initiate discussion with the following question: "If specific cancers arise as a result of, typically, 5-7 mutations in key genes, how does one explain the progression of tumors from being localized in the tissue of origin to being metastatic such that they can invade distant sites in the body?"

	Have students go to [[http://www.insidecancer.org]] and watch the section on "Promoting Mutations"		Have students go to [[http://www.insidecancer.org]] and watch the section on "Promoting Mutations"

Danielkainer: New page: '''== Stability Genes & Their Roles in Carcinogenesis ==''' ---- '''Lesson Overview''' Students read an overview of the types of gene mutations can contribute to carcinogenesis. They l...

Danielkainer — Fri, 11 Apr 2008 22:04:41 GMT

New page: '''== Stability Genes & Their Roles in Carcinogenesis ==''' ---- '''Lesson Overview''' Students read an overview of the types of gene mutations can contribute to carcinogenesis. They l...

New page

'''== Stability Genes & Their Roles in Carcinogenesis =='''

----
'''Lesson Overview'''
Students read an overview of the types of gene mutations can contribute to carcinogenesis. They learn about stability genes and how defects in these genes promote cancer development in the "Promoting Mutations" subsection of the "Hallmarks of Cancer" section of the InsideCancer.org site. Each student pair will select a specific stability gene linked to cancer and will compare its wild type function in normal cells with its transformed function in tumor cells.

--------------------------------------------------------------------------------

'''== Goals and Objectives =='''

Students will:
1. Explain what a stability gene is and the role that they play in cancer development and promotion.
2. Choose a specific hallmark gene and describe its role in certain cancers

'''==
Common Misconceptions =='''

Students are frequently taught that two types of genes mutate during carcinogenesis: those that promote progression through the cell cycle, and those that inhibit such progression. While this generalization is accurate, it is not complete. For example, it leaves out stability gene mutations, which result in an overall net increase in new mutations, thus enhancing the likelihood that tumor cells will develop new phenotypes.

--------------------------------------------------------------------------------

'''== The Lesson =='''

'''== Preparation Before class: =='''
A concise document, based on the article "The Hallmarks of Cancer" will be provided to give background about the mechanisms of carcinogenesis.

'''== During class =='''

Initiate discussion with the following question: "If specific cancers arise as a result of, typically, 5-7 mutations in key genes, how does one explain the progression of tumors from being localized in the tissue of origin to being metastatic such that they can invade distant sites in the body?"

Have students go to [[http://www.insidecancer.org]] and watch the section on "Promoting Mutations"

Divide students into pairs and help them choose a specific stability gene to research

'''== Describe the activity. =='''

Student partners will select (or be assigned) a stability gene and will utilize web-based resources, including www.insidecancer.org, to explore molecular mechanisms by which tumors progress through stages and alter their phenotypes.

'''== Time required =='''

2-3 class periods, the last of which will include an informal presentation to the rest of the class.